Gore, among the NFL's leaders in yards rushing and all-purpose yards, was hurt when a pile of tacklers fell on his leg as he stretched to reach the first-down marker on the second play of the second half. He kept his weight off his left ankle as two trainers helped him to the bench, and he left the field sitting in the passenger seat of a cart moments later.

Gore had 52 yards on 14 carries when he left. He also made a 4-yard touchdown reception with 46 seconds left in the first half, putting the 49ers ahead 14-7. DeShaun Foster replaced him.